05487390 is referenced by 132 patents and cites 25 patents.

Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microcapsules is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microcapsules are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microcapsules can optionally be linked with ligands that minimize tissue adhesion or that target the microcapsules to specific regions.

Title
Gas-filled polymeric microbubbles for ultrasound imaging
Application Number
593684
Publication Number
5487390
Application Date
January 14, 1994
Publication Date
January 30, 1996
Inventor
Robert S Langer
Newton
MA, US
Harry R Allcock
State College
PA, US
Margaret Wheatley
Media
PA, US
Alexander K Andrianov
Belmont
MA, US
Smadar Cohen
Petach-Tickva
IL
Agent
Arnall Golden & Gregory
Assignee
The Penn State Research Foundation
PA, US
Massachusetts Institute of Technology
MA, US
IPC
A61K 9/50
A61B 8/14
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